Article
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine.
Brain research - 5 Jan 2006
Liu Qing-Rong, Lu Lin, Zhu Xu-Guang, Gong Jian-Ping, Shaham Yavin, Uhl George R
Abstract excerpt
Results from studies using molecular and genetic methods in humans and rodents suggest that brain-derived neurotrophic factor (BDNF) is involved in the behavioral effects of abused drugs, making understanding of its genomic structure and regulation of substantial interest. Recently, we have reported that the human BDNF gene contains seven upstream exons that can each be spliced independently to the major BDNF...
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