Article
Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions.
BMC bioinformatics - 1 Jan 2000
Edwards J S, Palsson B O
Abstract excerpt
BACKGROUND: Genome sequencing and bioinformatics are producing detailed lists of the molecular components contained in many prokaryotic organisms. From this 'parts catalogue' of a microbial cell, in silico representations of integrated metabolic functions can be constructed and analyzed using flux balance analysis (FBA). FBA is particularly well-suited to study metabolic networks based on genomic, biochemical,...
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