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Article

Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease.

Journal of negative results in biomedicine - 22 Dec 2005

Hansen Wiebke, Saft Carsten, Andrich Jürgen, Müller Thomas, Wieczorek Stefan, Epplen Jörg T, Arning Larissa

Abstract excerpt

BACKGROUND: Huntington disease (HD) is a fully penetrant, autosomal dominantly inherited disorder associated with abnormal expansions of a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of repeat units is highly predictive for the age at onset (AO) of the disorder. But AO is only modestly correlated with repeat length when intermediate HD expansions are considered. Recently, suggestive...

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Identifiers

PMID: 16372906
DOI: 10.1186/1477-5751-4-12
PMCID: PMC1327683

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease.PMID 16372906Read ↗

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