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Article

The impact of single-nucleotide polymorphisms (SNPs) in OGG1 and XPC on the age at onset of Huntington disease.

Mutation research - 15 Aug 2013

Berger Frédérique, Vaslin Laurence, Belin Lisa, Asselain Bernard, Forlani Sylvie, Humbert Sandrine, Durr Alexandra, Hall Janet

Abstract excerpt

The age at onset of Huntington disease (HD) shows a strong, negative correlation with the number of CAG repeats within the huntingtin (HTT) gene. However, this does not account for all the inter-individual variability seen among patients. In order to assess whether single-nucleotide polymorphisms (SNPs) in the OGG1 and XPC genes, both implicated in responses to oxidative stress, are associated with the age of...

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Source

Identifiers

PMID: 23830927
DOI: 10.1016/j.mrgentox.2013.04.020

Genes

OGG1
XPC
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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