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Article

Ionization of zwitterionic amine substrates bound to monomeric sarcosine oxidase.

Biochemistry - 27 Dec 2005

Zhao Gouhua, Jorns Marilyn Schuman

Abstract excerpt

Monomeric sarcosine oxidase (MSOX) binds the L-proline zwitterion (pKa = 10.6). The reactive substrate anion is generated by ionization of the ES complex (pKa = 8.0). Tyr317 was mutated to Phe to determine whether this step might involve proton transfer to an active site base. The mutation does not eliminate the ionizable group in the ES complex (pKa = 8.9) but does cause a 20-fold decrease in the maximum rate of...

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Identifiers

PMID: 16363800
DOI: 10.1021/bi051898d
PMCID: PMC2764489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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