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Article

The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.

Proteins - 1 Jun 2008

Ilari Andrea, Bonamore Alessandra, Franceschini Stefano, Fiorillo Annarita, Boffi Alberto, Colotti Gianni

Abstract excerpt

The X-ray structure of monomeric N-methyltryptophan oxidase from Escherichia coli (MTOX) has been solved at 3.2 A resolution by molecular replacement methods using Bacillus sp. sarcosine oxidase structure (MSOX, 43% sequence identity) as search model. The analysis of the substrate binding site highlights the structural determinants that favour the accommodation of the bulky N-methyltryptophan residue in MTOX. In...

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Identifiers

PMID: 18186483
DOI: 10.1002/prot.21898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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