Article
Association between migraine and HLA-DRB1 gene polymorphisms.
The journal of headache and pain - 1 Sept 2005
Rainero Innocenzo, Fasano Edvige, Rubino Elisa, Rivoiro Chiara, Valfrè Walter, Gallone Salvatore, Savi Lidia, Gentile Salvatore, Lo Giudice Rossana, De Martino Paola, Dall'Omo Anna Maria, Pinessi Lorenzo
Abstract excerpt
We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and...
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