Article
HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe.
Journal of neuroimmunology - 1 May 2004
Ballerini Clara, Guerini Franca R, Rombolà Giovanni, Rosati Eleonora, Massacesi Luca, Ferrante Pasquale, Caputo Domenico, Talamanca Lorenzo Figà, Naldi Paola, Liguori Maria, Alizadeh Mehdi, Momigliano-Richiardi Patricia, D'Alfonso Sandra
Abstract excerpt
The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c)<10(-6); Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; p(c)=0.047) and DRB1*07 decreased (OR=0.60; p(c)=1.3 x 10(-3)) independently of DR15 and of each other. We...
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