Article
Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura.
Neuroscience letters - 10 Feb 2005
Kowa Hisanori, Fusayasu Emi, Ijiri Tamami, Ishizaki Kumiko, Yasui Kenichi, Nakaso Kazuhiro, Kusumi Masayoshi, Takeshima Takao, Nakashima Kenji
Abstract excerpt
Recently, several angiotensin I-converting enzyme (ACE) inhibitors and an angiotensin II receptor blocker were demonstrated to have a clinically important prophylactic effect in migraine. ACE is one of the key enzymes in the rennin-angiotensin-aldosterone system, which modulates vascular tension and blood pressure. In humans, serum ACE levels are strongly genetically determined. Individuals who were homozygous...
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