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Article

An association study between the transthyretin (TTR) gene and mental retardation.

European archives of psychiatry and clinical neuroscience - 1 Jun 2006

Li Jun, Gao Jian-Jun, Zhang Fu-Chang, Xing Qing-He, Dang Fang-Li, Gao Xiao-Cai, Duan Shi-Wei, Zheng Zi-Jian, Qian Xue-Qing, Qin Wei, Li Xing-Wang, Han Yan-Feng, Li Jing, Feng Guo-Yin, St Clair D, He Lin

Abstract excerpt

It is known that in the pathogenesis of mental retardation (MR), both genetic and environmental factors (particularly iodine deficiency) appear to play a critical role. Transthyretin (TTR) transports between 20% and 30% of serum thyroxine in normal individuals and it is the main T(4)-binding protein in CSF. Variability in the TTR gene may influence risk for iodine-deficiency-based MR. The SNPs we selected from...

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Source

Identifiers

PMID: 16362527
DOI: 10.1007/s00406-005-0630-6

Genes

TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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