Article
A family-based association study of dopamine receptor D4 and mental retardation in Qinba region of China.
Neuroscience letters - 10 May 2012
Zhang Kejin, Zhang Meijie, He Hongjuan, Zhang Jing, Chi Wanyu, Guo Yale, Huang Shaoping, Zheng Zijian, Zhang Fuchang, Gao Xiaocai
Abstract excerpt
Dopamine receptor D4 (DRD4) is activated by the neurotransmitter dopamine and links to many neurological and psychiatric conditions because of its close relationship with prefrontal cortex and other important brain regions. To explore the possibility that genetic variants of DRD4 gene predispose to children with mental retardation (MR), five target SNPs of DRD4 were selected and genotyped in the samples of 163 MR...
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