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Article

Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients.

Neuroreport - 23 Jan 2006

Han Doug Hyun, Kee Baik Seok, Min Kyung Joon, Lee Young Sik, Na Chul, Park Doo Byung, Lyoo In Kyoon

Abstract excerpt

We assessed catechol-O-methyltransferase (COMT) polymorphism in 132 first-onset schizophrenic patients and 80 healthy controls. The relationship between COMT polymorphism and cognitive function, aggression and psychiatric symptoms was tested in the schizophrenic group. COMTL carrier had higher digit span score and lower similarity score than COMTH homozygote. COMTL carrier had higher attention and delusion scores...

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Source

Identifiers

PMID: 16361958
DOI: 10.1097/01.wnr.0000192740.38653.91

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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