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Article

Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2005

Brugge J M, Simioni P, Bernardi F, Tormene D, Lunghi B, Tans G, Pagnan A, Rosing J, Castoldi E

Abstract excerpt

BACKGROUND: Functional defects of the protein C pathway, detectable in plasma as activated protein C (APC) resistance, are a prevalent risk factor for venous thrombosis. The factor V (FV) Leiden mutation causes APC resistance by interfering with the APC-mediated inactivation of both FVa and FVIIIa. Co-inheritance of FV Leiden and quantitative FV deficiency on different alleles, a rare condition known as...

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Identifiers

PMID: 16359508
DOI: 10.1111/j.1538-7836.2005.01634.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation.PMID 16359508Read ↗

"Pseudo homozygous" activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with thrombosis: report of two cases belonging to two unrelated kindreds.Semantic proximity Read ↗

Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.Semantic proximity Read ↗

Molecular bases of pseudo-homozygous APC resistance: the compound heterozygosity for FV R506Q and a FV null mutation results in the exclusive presence of FV Leiden molecules in plasma.Semantic proximity Read ↗

Pseudohomozygosity for activated protein C resistance is a risk factor for venous thrombosis.Semantic proximity Read ↗

APC resistance: biological basis and acquired influences.Semantic proximity Read ↗

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Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

Coagulation factor V and thrombophilia: background and mechanisms.Semantic proximity Read ↗

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