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Article

Tumor-targeted therapy with a conditionally replicating mutant of HSV-1 induces regression of xenografted human hepatomas.

Cancer biology & therapy - 1 Nov 2005

Xue Feng, Dong Chang-Yuan, Su Yue, Zhu Huabin, Ling Weifang, Liu Yingle, Xu Hua, Xiao Wei, Zhou Shumin, Qi Yi-Peng

Abstract excerpt

The selectively oncolytic effects of mtHSV, a HSV icp34.5 mutant with lacz gene insertion, on several tumor cells in vitro and its antitumor effects by the intratumoral (IT) route to nude mice loaded the human hepatoma xenografts were explored. The mtHSV could conditionally replicate in and lyse Hep-3B (human hepatoma cells), Hep-2 (human larynx cancer cells) and SPC-A1 (human lung cancer cells), but not MRC-5...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16357508
DOI: 10.4161/cbt.4.11.2094

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ADM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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