Article
Effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2006
Fu Xinping, Tao Lihua, Li Min, Fisher William E, Zhang Xiaoliu
Abstract excerpt
PURPOSE: Pancreatic cancer is a devastating disease that is almost universally fatal because of the lack of effective treatments. We recently constructed a novel oncolytic virus (FusOn-H2) from the type 2 herpes simplex virus. Because the replication potential of FusOn-H2 depends on the activation of the Ras signaling pathway, we evaluated its antitumor effect against pancreatic cancer, which often harbors K-ras...
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