Article
Human polymorphism and human-chimpanzee divergence in pseudoautosomal region correlate with local recombination rate.
Gene - 1 Mar 2006
Bussell Jennifer J, Pearson Nathaniel M, Kanda Ravinder, Filatov Dmitry A, Lahn Bruce T
Abstract excerpt
Previous studies have shown widespread correlation between nucleotide polymorphism and recombination rate, but the cause of this correlation is unresolved. One explanation is that recombination is associated with point mutations, potentially through mutagenic effects of meiotic crossover. This hypothesis predicts that regions of frequent recombination should show both elevated nucleotide diversity within a...
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