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Article

The C282Y mutation may have been positively selected as it mitigates the infertility of celiac disease.

Medical hypotheses - 1 Jan 2006

Whittington C

Abstract excerpt

Celiac disease and C282Y homozygous hemochromatosis have a similar increasing incidence across Europe. Both have gradients of frequency which increase from Turkey to North West Europe and culminate with a high frequency in Ireland. These two gradients follow the path of the Neolithic settlers who reached the edge of Europe at Ireland. Celiac disease and C282Y hereditary hemochromatosis have opposite effects on...

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Source

Identifiers

PMID: 16356657
DOI: 10.1016/j.mehy.2005.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The C282Y mutation may have been positively selected as it mitigates the infertility of celiac disease.PMID 16356657Read ↗

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