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Article

Celtic origin of the C282Y mutation of hemochromatosis.

Blood cells, molecules & diseases - 1 Dec 1998

Lucotte G

Abstract excerpt

The C282Y mutation in the HFE gene is the main mutation causing hemochromatosis, and C282Y frequencies have been reported for various European populations. The aim of this review is to compile the Y allele frequencies of the C282Y mutation for twenty European populations. The most elevated value (6.88%) is observed in residual Celtic populations in UK and France, in accordance to the hypothesis of Simon et al....

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Source

Identifiers

PMID: 9851897
DOI: 10.1006/bcmd.1998.0212

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Celtic origin of the C282Y mutation of hemochromatosis.PMID 9851897Read ↗

Celtic origin of the C282Y mutation of hemochromatosis.Semantic proximity Read ↗

Frequency analysis and allele map in favor of the celtic origin of the C282Y mutation of hemochromatosis.Semantic proximity Read ↗

A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?Semantic proximity Read ↗

Frequency of the hemochromatosis C282Y and H63D mutations in a Polish population of Slavic origin.Semantic proximity Read ↗

Frequency of the C282Y mutation of hemochromatosis in five French populations.Semantic proximity Read ↗

Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings.Semantic proximity Read ↗

Hemochromatosis in a Lithuanian with HFE C282Y homozygosity and C282Y allele frequencies in the Baltic Sea region.Semantic proximity Read ↗

Frequency of the C282Y and H63D mutations of the hemochromatosis gene (HFE) in a cohort of 1,000 neonates in Madrid (Spain).Semantic proximity Read ↗

The C282Y mutation may have been positively selected as it mitigates the infertility of celiac disease.Semantic proximity Read ↗

Longevity and carrying the C282Y mutation for haemochromatosis on the HFE gene: case control study of 492 French centenarians.Semantic proximity Read ↗

Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotypeSemantic proximity Read ↗

Uncommon mutations and polymorphisms in the hemochromatosis gene.Semantic proximity Read ↗

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