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Article

Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings.

Clinical genetics - 1 Jul 2003

Milman N, Pedersen P

Abstract excerpt

Hereditary hemochromatosis has been recognized as a clinical disorder for more than 100 years. The common form of the disorder is caused by the Cys282Tyr mutation (C282Y) of the HFE gene. Hereditary hemochromatosis affects predominantly people of Northern European origin. The C282Y mutation probably occurred on a single chromosome carrying the ancestral hemochromatosis haplotype, which subsequently was spread by...

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Source

Identifiers

PMID: 12791037
DOI: 10.1034/j.1399-0004.2003.00083.x

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings.PMID 12791037Read ↗

A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?Semantic proximity Read ↗

Celtic origin of the C282Y mutation of hemochromatosis.Semantic proximity Read ↗

Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden.Semantic proximity Read ↗

The origin and spread of the HFE-C282Y haemochromatosis mutation.Semantic proximity Read ↗

Celtic origin of the C282Y mutation of hemochromatosis.Semantic proximity Read ↗

Frequency analysis and allele map in favor of the celtic origin of the C282Y mutation of hemochromatosis.Semantic proximity Read ↗

Frequency of the hemochromatosis C282Y and H63D mutations in a Polish population of Slavic origin.Semantic proximity Read ↗

Unique genetic profile of hereditary hemochromatosis in Russians: high frequency of C282Y mutation in population, but not in patients.Semantic proximity Read ↗

Frequency of the C282Y and H63D mutations of the hemochromatosis gene (HFE) in a cohort of 1,000 neonates in Madrid (Spain).Semantic proximity Read ↗

Geography of HFE C282Y and H63D mutations.Semantic proximity Read ↗

Frequency of the hemochromatosis HFE mutations C282Y, H63D, and S65C in blood donors in the Faroe Islands.Semantic proximity Read ↗

Definition of C282Y mutation in a hereditary hemochromatosis family from Turkey.Semantic proximity Read ↗

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