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Article

The evolutionary adaptation of the C282Y mutation to culture and climate during the European Neolithic.

American journal of physical anthropology - 1 May 2016

Heath Kathleen M, Axton Jacob H, McCullough John M, Harris Nathan

Abstract excerpt

OBJECTIVES: The C282Y allele is the major cause of hemochromatosis as a result of excessive iron absorption. The mutation arose in continental Europe no earlier than 6,000 years ago, coinciding with the arrival of the Neolithic agricultural revolution. Here we hypothesize that this new Neolithic diet, which originated in the sunny warm and dry climates of the Middle East, was carried by migrating farmers into the...

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Identifiers

PMID: 26799452
DOI: 10.1002/ajpa.22937
PMCID: PMC5066702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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