Article
Haplotype association analysis of AGT variants with hypertension-related traits: the HyperGEN study.
Human heredity - 1 Jan 2005
Gu C Charles, Chang Yen-Pei C, Hunt Steven C, Schwander Karen, Arnett Donna, Djousse Luc, Heiss Gerardo, Oberman Al, Lalouel Jean-Marc, Province Mike, Chakravarti Aravinda, Rao D C
Abstract excerpt
OBJECTIVE: Function of the renin-angiotensin system is important to human hypertension, but its genetic etiology remains elusive. We set out to examine a hypothesis that multiple genetic variants in the system act together in blood pressure regulation, via intermediate phenotypes such as blood pressure reactivity. METHODS: A sample of 531 hypertensive cases and 417 controls was selected from the HyperGEN study....
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