Article
Transforming growth factor-beta: its effect on phenotype reexpression by dedifferentiated chondrocytes in the presence and absence of osteogenin.
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Jun 1992
Harrison E T, Luyten F P, Reddi A H
Abstract excerpt
The single and combined actions of transforming growth factor (TGF)-beta and osteogenin were evaluated with regard to induction of colony formation and reexpression of the differentiated phenotype by dedifferentiated rabbit articular chondrocytes in soft agarose under serum-free conditions. TGF-beta alone did not promote colony formation and induced accumulation of proteoglycans and type II collagen at...
Topics
- Animals
- Bone Morphogenetic Protein 3
- Bone Morphogenetic Proteins
- Cartilage, Articular
- Cell Differentiation
- Cells, Cultured
- Collagen
- Glycosaminoglycans
- Growth Substances
- Phenotype