Article
Evidence for genetic heterogeneity in hereditary hydronephrosis caused by pelvi-ureteric junction obstruction, with one locus assigned to chromosome 6p.
Human genetics - 1 Jul 1992
Izquierdo L, Porteous M, Paramo P G, Connor J M
Abstract excerpt
Hereditary hydronephrosis (MIM 143400) is an autosomal dominant trait that causes unilateral or bilateral pelvi-ureteric junction (PUJ) obstruction. Linkage analysis was undertaken in 5 families with hereditary PUJ obstruction using the major histocompatibility complex locus as a test marker. The...
Topics
- Chromosomes, Human, Pair 6
- Female
- Gene Expression
- Genes, Dominant
- Genetic Linkage
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Hydronephrosis
- Kidney Pelvis
- Lod Score
- Major Histocompatibility Complex
- Male
- Pedigree
- Ureteral Obstruction