Article
Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1.
American journal of human genetics - 1 Apr 2000
Feather S A, Malcolm S, Woolf A S, Wright V, Blaydon D, Reid C J, Flinter F A, Proesmans W, Devriendt K, Carter J, Warwicker P, Goodship T H, Goodship J A
Abstract excerpt
Primary vesicoureteric reflux (VUR) affects 1%-2% of whites, and reflux nephropathy (RN) causes up to 15% of end-stage renal failure in children and adults. There is a 30-50-fold increased incidence of VUR in first-degree relatives of probands, compared with the general population. We report the results of the first genomewide search of VUR and RN; we studied seven European families whose members exhibit...
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