Article
A genome scan in affected sib-pairs with familial vesicoureteral reflux identifies a locus on chromosome 5.
European journal of human genetics : EJHG - 1 Feb 2010
Briggs Christine E, Guo Chao-Yu, Schoettler Cynthia, Rosoklija Ilina, Silva Andres, Bauer Stuart B, Retik Alan B, Kunkel Louis, Nguyen Hiep T
Abstract excerpt
The basis for vesicoureteral reflux (VUR) is considered to be primarily genetic, with a 30-50% incidence of VUR in first-degree relatives of patients. The search for the causative gene or genes has been elusive, likely because of VUR being genetically heterogeneous with complex inheritance patterns. In this study, a genome-wide analysis of VUR with high-density single nucleotide polymorphisms was conducted with...
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