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Article

Reduced allergenic potency of VR9-1, a mutant of the major shrimp allergen Pen a 1 (tropomyosin).

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2005

Reese Gerald, Viebranz Julia, Leong-Kee Susan M, Plante Matthew, Lauer Iris, Randow Stefanie, Moncin Mar San-Miguel, Ayuso Rosalia, Lehrer Samuel B, Vieths Stefan

Abstract excerpt

The major shrimp allergen, tropomyosin, is an excellent model allergen for studying the influence of mutations within the primary structure on the allergenic potency of an allergen; Pen a 1 allows systematic evaluation and comparison of Ab-binding epitopes, because amino acid sequences of both allergenic and nonallergenic tropomyosins are known. Individually recognized IgE Ab-binding epitopes, amino acid...

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Identifiers

PMID: 16339577
DOI: 10.4049/jimmunol.175.12.8354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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