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Article

Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2006

Feagins Linda A, Susnow Nathan, Zhang Hui Ying, Pearson Stephanie, Owen Charles, Schmalstieg William F, Terada Lance S, Spechler Stuart J, Ramirez Ruben D, Souza Rhonda F

Abstract excerpt

The IGF-II gene normally exhibits genomic imprinting, a DNA modification that allows the expression of only one of the two inherited alleles. With loss of imprinting, there is a gain of allelic gene expression (GOAGE) due to IGF-II being expressed by both alleles. GOAGE for IGF-II has been demonstrated in a number of malignancies and in normal epithelia surrounding malignancies, but not in epithelia without...

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Identifiers

PMID: 16339295
DOI: 10.1152/ajpgi.00383.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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