Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR.

Journal of experimental & clinical cancer research : CR - 1 Dec 2006

Xu W, Fan H, He X, Zhang J, Xie W

Abstract excerpt

In the present study, IGF2 mRNA expression was examined by semi-quantitative RT-PCR in 46 esophageal cancer cases. LOI of IGF2 was detected in informative samples, which were determined as heterozygote with ApaI polymorphism in exon 9 of IGF2 by PCR-RFLP and RT-PCR-RFLP. Methylation status of IGF2 DMR in informative samples was analyzed by sodium bisulfite treatment and PCR and the following cloning sequencing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Esophageal Neoplasms
Share to Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor II

Share to Methylation

Share to Polymorphism, Restriction Fragment Length

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Neoplasm

Source

Identifiers

PMID: 17310846

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR.PMID 17310846Read ↗

H19 DMR methylation correlates to the progression of esophageal squamous cell carcinoma through IGF2 imprinting pathway.Semantic proximity Read ↗

Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues.Semantic proximity Read ↗

Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.Semantic proximity Read ↗

Insulin-Like Growth Factor 2 (IGF2) Signaling in Colorectal Cancer—From Basic Research to Potential Clinical ApplicationsSemantic proximity Read ↗

IGF2 DMR0 Methylation, Loss of Imprinting, and Patient Prognosis in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpressionSemantic proximity Read ↗

Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer.Semantic proximity Read ↗

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.Semantic proximity Read ↗

Loss of imprinting and overexpression of IGF2 gene in gastric adenocarcinoma.Semantic proximity Read ↗

Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus.Semantic proximity Read ↗

Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.Semantic proximity Read ↗

Differential expression patterns of the insulin-like growth factor 2 gene in human colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.