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Article

High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2010

Lin Zhicheng, Zhao Ying, Chung Chee Yeun, Zhou Yanhong, Xiong Nian, Glatt Charles E, Isacson Ole

Abstract excerpt

SLC18A2 encodes the vesicular monoamine transporter 2 protein that regulates neurotransmission and reduces cytosolic toxicity of monoamines. Deletion of this gene causes lethality in mice, and DNA sequence variation in this gene is associated with alcoholism and Parkinson's disease, among other d...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20181938
DOI: 10.1096/fj.09-140368
PMCID: PMC2887259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20181938-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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