Article
Glucose transporter polymorphisms are associated with clear-cell renal carcinoma.
Cancer genetics and cytogenetics - 1 Dec 2005
Page Tobias, Hodgkinson Andrea D, Ollerenshaw Martin, Hammonds John C, Demaine Andrew G
Abstract excerpt
Clear-cell renal cell carcinoma (CCRCC) is identified by abundant glycogen-rich cytoplasm, due to the aberrant influx and storage of glucose. The objective was to investigate the frequency of polymorphisms of the facilitative glucose transporter (GLUT1). GLUT1 is a downstream target of Hypoxia-inducible factor (HIF-1alpha), a mediator of hypoxia-controlled angiogenesis. In this study, we examine the allelic...
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