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Article

Inefficient processing impairs release of RNA from the site of transcription.

The EMBO journal - 17 May 1999

Custódio N, Carmo-Fonseca M, Geraghty F, Pereira H S, Grosveld F, Antoniou M

Abstract excerpt

We describe here for the first time the site of retention within the nucleus of pre-mRNA processing mutants unable to be exported to the cytoplasm. Fluorescence in situ hybridization was used to detect transcripts from human beta-globin genes that are either normal or defective in splicing or 3' end formation. Nuclear transcripts of both wild-type and mutant RNAs are detected only as intranuclear foci that...

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Identifiers

PMID: 10329631
DOI: 10.1093/emboj/18.10.2855
PMCID: PMC1171366

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