Article
Oxidative stress imbalance and cellular damage mediated by the ND4 G11778A mutation.
Scientific reports - 21 Feb 2026
Fang Lijun, Fu Kangyue, Yang Mengyu, Xu Yiwen, Ukamaka Ezeugwu Sussan, Qu Dianbo, Huang Tianwen, Hu Jianzhang
Abstract excerpt
The mechanisms underlying cellular damage induced by the mitochondrially encoded NADH dehydrogenase subunit 4 (MT-ND4) with R340H mutation caused by the variant m.11778G > A in complex I are intricate. Numerous studies indicate that mitochondria play a primary role in cellular death due to this mutation. However, the detailed pathological effects remain incompletely elucidated. To decipher the specific impacts of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.