Article

Efficient Production of Human Hyaluronidase PH20 in HEK293T Cells Using Site Specific Integration

2021-02-22

Abstract excerpt

PH20 is hyaluronidase that hydrolyze the glycosidic bond of hyaluronic acid as a major proteoglycan found in extracellular matrices. PH20 is used in the subcutaneous space to increase the dispersion and absorption of co-administered drugs. PH20 is also injected against solid tumors for to better penetration of anticancer agents into the tumor tissue and inhibiting the tumor cell growth. In the present study, we ha...

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Literature Corpus work: 36e4ceae-69d5-51ab-8b1a-4fb3b35e42e7
DOI: 10.21203/rs.3.rs-215087/v1

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