Article
From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue.
International journal of oncology - 1 Jan 2006
Zhuang Zhengping, Huang Steve, Kowalak Jeff A, Shi Ying, Lei Jingqi, Furuta Makoto, Lee Youn-Soo, Lubensky Irina A, Rodgers Griffin P, Cornelius Albert S, Weil Robert J, Teh Bin T, Vortmeyer Alexander O
Abstract excerpt
Correlation of disease phenotype with protein profile (proteotype) is a significant challenge for biomedical research. The main obstacles have been the need to insure sufficient quantities of pure protein sample, the reproducibility of protein display, and rapid and accurate protein identification. We present a modified approach that combines enhanced detection sensitivity with tissue microdissection from frozen...
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