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Minimal Change Disease: Pathogenetic Insights from Glomerular Proteomics

21 May 2024

Abstract excerpt

The mechanism underlying podocyte dysfunction in minimal change disease (MCD) remains unknown. This study aimed to shed light on the potential pathophysiology of MCD using glomerular proteomic analysis. Shotgun proteomics using label-free quantitative mass spectrometry was performed on formalin-fixed, paraffin-embedded (FFPE) renal biopsies from two groups of samples: control (CTR) and MCD. Glomeruli were excised...

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PMID: 38891801
DOI: 10.3390/ijms25115613

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