Article
Candidate Genes for Nonsyndromic Cleft Palate Detected by Exome Sequencing.
Journal of dental research - 1 Oct 2017
Hoebel A K, Drichel D, van de Vorst M, Böhmer A C, Sivalingam S, Ishorst N, Klamt J, Gölz L, Alblas M, Maaser A, Keppler K, Zink A M, Dixon M J, Dixon J, Hemprich A, Kruse T, Graf I, Dunsche A, Schmidt G, Daratsianos N, Nowak S, Aldhorae K A, Nöthen M M, Knapp M, Thiele H, Gilissen C, Reutter H, Hoischen A, Mangold E, Ludwig K U
Abstract excerpt
Nonsyndromic cleft palate only (nsCPO) is a facial malformation that has a livebirth prevalence of 1 in 2,500. Research suggests that the etiology of nsCPO is multifactorial, with a clear genetic component. To date, genome-wide association studies have identified only 1 conclusive common variant for nsCPO, that is, a missense variant in the gene grainyhead-like-3 ( GRHL3). Thus, the underlying genetic causes of...
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