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Article

Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.

Journal of molecular biology - 20 Jan 2006

Marchini Antonio, Daeffler Laurent, Marttila Tiina, Schneider Katja U, Blaschke Rüdiger J, Schnölzer Martina, Rommelaere Jean, Rappold Gudrun

Abstract excerpt

Mutations within the homeobox SHOX gene have been associated with short stature and the skeletal deformities found in Léri-Weill, Turner and Langer syndromes implying an involvement of SHOX in growth and bone formation. Despite its clinical significance, the precise role of SHOX and the mechanisms that modulate its functions remain unknown. We reported previously that SHOX is a nuclear protein that specifically...

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Source

Identifiers

PMID: 16325853
DOI: 10.1016/j.jmb.2005.11.007

Genes

SHOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.PMID 16325853Read ↗

The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.Semantic proximity Read ↗

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The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome.Semantic proximity Read ↗

SHOX triggers the lysosomal pathway of apoptosis via oxidative stress.Semantic proximity Read ↗

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