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Article

SHOX triggers the lysosomal pathway of apoptosis via oxidative stress.

Human molecular genetics - 15 Mar 2014

Hristov Georgi, Marttila Tiina, Durand Claudia, Niesler Beate, Rappold Gudrun A, Marchini Antonio

Abstract excerpt

The SHOX gene encodes for a transcription factor important for normal bone development. Mutations in the gene are associated with idiopathic short stature and are responsible for the growth failure and skeletal defects found in the majority of patients with Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia. SHOX is expressed in growth plate chondrocytes where it is supposed to modulate the...

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Source

Identifiers

PMID: 24186869
DOI: 10.1093/hmg/ddt552

Genes

SHOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SHOX triggers the lysosomal pathway of apoptosis via oxidative stress.PMID 24186869Read ↗

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