Article
The molecular genetics of breast cancer: the contribution of comparative genomic hybridization.
Pathology, research and practice - 1 Jan 2005
Reis-Filho Jorge S, Simpson Peter T, Gale Theodora, Lakhani Sunil R
Abstract excerpt
Comparative genomic hybridization (CGH) has been the technique of choice over the last 10 years for mapping DNA copy number changes in human tumors. Here we review the literature to demonstrate how CGH has contributed to the comprehension of molecular aspects of breast tumorigenesis. At least two distinct molecular pathways of breast cancer have been characterized that show a strong correlation with histological...
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