Article
Genotypic prognostic markers.
Current topics in microbiology and immunology - 1 Jan 2005
Stilgenbauer S, Döhner H
Abstract excerpt
In chronic lymphocytic leukemia (CLL), genetic analyses by fluorescence in situ hybridization (FISH) and DNA sequencing have greatly improved our understanding of pathogenic events and prognostic markers. On the one hand, there are genomic aberrations, which are detected in over 80% of CLL cases, and genes potentially involved in pathogenesis were identified with ATM in a subset of cases with 11q deletion and p53...
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