1-Deoxy- <scp>d</scp> -Xylulose 5-Phosphate Reductoisomerase (IspC) from <i>Mycobacterium tuberculosis</i> : towards Understanding Mycobacterial Resistance to Fosmidomycin

Abstract excerpt

1-Deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) catalyzes the first committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway and is a potential drug target in some pathogenic bacteria. The antibiotic fosmidomycin has been shown to inhibit IspC in a number of organisms and is active against most gram-negative bacteria but not gram positives, including Mycobacterium...

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