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Article

D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias.

Genes, chromosomes & cancer - 1 Apr 2006

Schnittger Susanne, Kohl Tobias M, Leopold Nina, Schoch Claudia, Wichmann H-Erich, Kern Wolfgang, Lohse Peter, Hiddemann Wolfgang, Haferlach Torsten, Spiekermann Karsten

Abstract excerpt

Mutations within the FLT3 gene are of growing importance for classification, risk assessment, and therapeutic targeting of acute myeloid leukemia (AML). We analyzed 656 AML patients for a recently described single-nucleotide polymorphism (SNP) in the third immunoglobulin-like domain of the extracellular region of FLT3. The FLT3 D324N variant was present in 42 cases (6.4%), but it was not associated with a...

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Identifiers

PMID: 16320249
DOI: 10.1002/gcc.20294

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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