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Article

Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans.

Journal of pharmacokinetics and pharmacodynamics - 1 Aug 2005

Buchwald Peter, Juhász Attila, Bell Cynthia, Pátfalusi Márta, Howes John, Bodor Nicholas

Abstract excerpt

The N-acetylation of the noncompetitive AMPA antagonist talampanel (TLP) represents a route of varying significance in various species. For a detailed analysis in humans, plasma concentrations of TLP and its N-acetyl metabolite (NAc-TLP) were measured for up to 48 h after administration of a single oral dose of 75 mg in 28 healthy volunteers following genotyping for the N-acetyltansferase NAT2 isozymes (alleles...

Read the complete abstract on PubMed

Topics

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Share to Acetylation
Share to Administration, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anti-Anxiety Agents

Share to Arylamine N-Acetyltransferase

Share to Benzodiazepines

Share to Models, Biological

Share to Polymorphism, Genetic

Share to Receptors, AMPA

Source

Identifiers

PMID: 16320099
DOI: 10.1007/s10928-005-0001-y

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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