Article
Crystal structure and functional studies reveal that PAS factor from Vibrio vulnificus is a novel member of the saposin-fold family.
Journal of molecular biology - 20 Jan 2006
Lee Jun Hyuck, Yang Sung-Tae, Rho Seong-Hwan, Im Young Jun, Kim Soo Young, Kim Young Ran, Kim Mun-Kyoung, Kang Gil Bu, Kim Jae Il, Rhee Joon Haeng, Eom Soo Hyun
Abstract excerpt
PAS factor is a novel putative bacterial secretion factor thought to induce secretion of periplasmic proteins. We solved the crystal structure of PAS factor from Vibrio vulnificus at 1.8A resolution and found it to be comprised of five alpha helices that form an antiparallel bundle with an up-and-down topology, and to adopt the saposin-fold characteristic of a family of proteins that bind to membranes and lipids....
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