Article
A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains.
The Journal of biological chemistry - 3 Feb 2006
Wegrzyn Renee D, Hofmann Diana, Merz Frieder, Nikolay Rainer, Rauch Thomas, Graf Christian, Deuerling Elke
Abstract excerpt
In eukaryotes, newly synthesized proteins interact co-translationally with a multitude of different ribosome-bound factors and chaperones including the conserved heterodimeric nascent polypeptide-associated complex (NAC) and a Hsp40/70-based chaperone system. These factors are thought to play an important role in protein folding and targeting, yet their specific ribosomal localizations, which are prerequisite for...
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