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Article

Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.

Biochemical and biophysical research communications - 6 Jan 2006

Isobe Tomoyasu, Uchida Chiharu, Hattori Takayuki, Kitagawa Kyoko, Oda Toshiaki, Kitagawa Masatoshi

Abstract excerpt

Adenovirus E1A protein perturbs the cell cycle and promotes cell transformation. Although E1A is relatively unstable, regulation of E1A stability has not been fully elucidated. Here, we showed that E1A was ubiquitinated and degraded using a proteasome in vivo system. Interestingly, we found that BS69, one of the E1A-binding proteins, inhibited ubiquitination of E1A. BS69 mutants lacking the MYND domain could not...

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Identifiers

PMID: 16300738
DOI: 10.1016/j.bbrc.2005.11.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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