Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer.

doi:10.1016/j.bbrc.2008.11.102

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Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer.

Biochemical and biophysical research communications - 23 Jan 2009

Kameda Hiroyuki, Watanabe Masashi, Bohgaki Miyuki, Tsukiyama Tadasuke, Hatakeyama Shigetsugu

Abstract excerpt

Cytoplasmic zinc finger protein A20 functionally dampens inflammatory signals and apoptosis via inhibition of NF-kappaB activation. We have reported that Ymer interacts with A20 and lysine (K)-63-linked polyubiquitin chain and that Ymer inhibits NF-kappaB signaling in collaboration with A20. It h...

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Inhibition of NF-kappaB signaling via tyrosine phosphorylation of Ymer.

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