Article
Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study.
Experimental gerontology - 1 Jan 2006
Ravaglia Giovanni, Paola Forti, Maioli Fabiola, Martelli Mabel, Montesi Fausta, Bastagli Luciana, Bianchin Marisa, Chiappelli Martina, Tumini Emanuela, Bolondi Luigi, Licastro Federico
Abstract excerpt
Risk of incident dementia from any cause and Alzheimer's disease (AD) in relation to the IL-1beta-511 (C-->T) and IL-6-174 (G-->C) polymorphisms was investigated in an Italian elderly cohort (n=791) with 4 years of follow-up. Analyses were adjusted for socio-demographic confounders (age, gender, education), presence of the Apolipoprotein E-epsilon4 allele, and plasma total homocysteine (tHcy), a newly proposed AD...
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