Article
Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis?
International journal of cancer - 15 Apr 2006
Cross Simon S, Yang Zhiyong, Brown Nicola J, Balasubramanian Sabapathy P, Evans Clair A, Woodward Julia K, Neville-Webbe Helen L, Lippitt Jenny M, Reed Malcolm W R, Coleman Robert E, Holen Ingunn
Abstract excerpt
The progression of cancer depends on the establishment of a tumour blood supply, and therefore tumour angiogenesis has been identified as a major target for new anticancer agents. Recent reports have suggested that osteoprotegerin (OPG) is involved in the control of endothelial cell survival through the inhibition of the activity of tumour necrosis factor- (TNF) related apoptosis-inducing ligand (TRAIL). The role...
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