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Article

A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1.

The Journal of biological chemistry - 13 Jan 2006

Meyer Rosana D, Mohammadi Moosa, Rahimi Nader

Abstract excerpt

VEGFR-1 is a kinase-defective receptor tyrosine kinase (RTK) and negatively modulates angiogenesis by acting as a decoy receptor. The decoy characteristic of VEGFR-1 is required for normal development and angiogenesis. To date, there is no molecular explanation for this unusual characteristic of VEGFR-1. Here we show that the molecular mechanisms underlying the decoy characteristic of VEGFR-1 is linked to the...

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Identifiers

PMID: 16286478
DOI: 10.1074/jbc.M506454200
PMCID: PMC1360223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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